GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2416257 | 1 | rs4304115 | chr5:110403346 | TSLP | chr5:110405778-110413722:+ | -0.28 | -3.53 | 0.000451 | Eosinophil counts |
| THCA | cis | rs2416257 | 1 | rs4304115 | chr5:110403346 | WDR36 | chr5:110427870-110466201:+ | 0.22 | 4 | 7.45E-5 | Eosinophil counts |
| THCA | cis | rs9346353 | 1 | rs4304126 | chr6:70512767 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.44 | 0.000626 | Sleep duration |
| THCA | cis | rs935334 | 1 | rs4304957 | chr14:76647572 | ESRRB | chr14:76837690-76968178:+ | 0.28 | 4.51 | 8.12E-6 | Blood pressure |
| THCA | cis | rs10927875 | 1 | rs4307563 | chr1:16313788 | CLCNKA | chr1:16345370-16360544:+ | 0.13 | 3.67 | 0.000267 | Dilated cardiomyopathy |
| THCA | cis | rs10927875 | 1 | rs4307563 | chr1:16313788 | HSPB7 | chr1:16340523-16346089:- | 0.55 | 11.19 | 5.77E-26 | Dilated cardiomyopathy |
| THCA | cis | rs10935120 | 1 | rs4309773 | chr3:134277301 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.58 | 1.56E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs4309773 | chr3:134277301 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.54 | 1.63E-10 | Height |
| THCA | cis | rs7923609 | 1 | rs4310508 | chr10:65138573 | NRBF2 | chr10:64893007-64914785:+ | -0.29 | -6.82 | 2.69E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs2243480 | 1 | rs431076 | chr7:65600320 | CCT6P1 | chr7:65216092-65228661:+ | 0.42 | 6.7 | 5.9E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs431076 | chr7:65600320 | CRCP | chr7:65579805-65619551:+ | -0.3 | -4.63 | 4.66E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs431076 | chr7:65600320 | LOC493754 | chr7:65993446-66057363:- | 0.29 | 3.36 | 0.000833 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs431076 | chr7:65600320 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.14 | 3.42E-12 | Diabetic kidney disease |
| THCA | cis | rs6748734 | 1 | rs4311055 | chr2:241821017 | C2orf54 | chr2:241825466-241835573:- | 0.3 | 6.54 | 1.56E-10 | Urinary metabolites |
| THCA | cis | rs6585827 | 1 | rs4311997 | chr10:124179299 | PLEKHA1 | chr10:124134220-124191866:+ | -0.21 | -5.76 | 1.47E-8 | Height |